MTHFR Gene Mutation and Pregnancy Every human has the gene known as 5-Methyltetrahydrofolate, but a significant percentage of humans have a mutation of that gene, simply known as MTHFR Mutation. MTHFR mutation boils down to the body’s inability to break down folate. Folate is imperative to the process of making DNA and modifying certain proteins as they relate to DNA. When looking closely into MTHFR, we find that people with this mutation have high levels of homocysteine. Homocysteine is the amino acid produced when proteins are broken down within the body. This high level of homocysteine can lead to arterial damage and blood clots. Hand in hand with this elevated homocysteine level, we find both a folate and vitamin B-12 deficiency. MTHFR mutation is hypothesized to affect 25% of hispanic people and 15% of white, and is likely to affect 40% of the overall population according to the genetic care and rare diseases information center. This mutation is not a random occurrence, in fact it